Before you order
The formula contains two serotonin precursors. If you take an antidepressant or certain other prescriptions, read this before you order.
IgniREM Sleep contains two compounds that raise serotonin. For most people that is unremarkable. If you take an antidepressant or certain other prescriptions, it is the one thing on this page you need to read before you order.
Do not start this product alongside any of them without asking the doctor who prescribed it. This is not a formality.
The formula includes L-tryptophan and 5-HTP. Both are precursors your body converts into serotonin, which is part of how sleep signalling works.
Medications in the list above also raise serotonin, by different routes. Stacking two sources can push serotonin activity too high, a reaction called serotonin syndrome. Mild cases bring agitation, sweating, shivering, a fast heartbeat, dilated pupils, tremor or diarrhoea. Severe cases involve high fever, muscle rigidity, confusion and seizures, and are a medical emergency.
It is uncommon. It is also well documented, and it is a real reason not to combine these casually. Your prescriber can tell you whether your particular medication and dose makes this a problem, and that answer is worth more than anything we can write here.
If you have started taking it and feel any of those symptoms — particularly agitation with sweating, shivering or a racing heart — stop taking it and contact a doctor. If symptoms are severe, treat it as an emergency.
This product was tested in adults aged 40 to 76. We have no data in anyone younger than 40, and none at all in children or adolescents. Do not give it to a minor.
Two capsules deliver 1,200 mg of a proprietary blend containing:
| Ingredient | Commonly used for |
|---|---|
| Glycine | An amino acid involved in sleep onset and body temperature regulation |
| L-tryptophan | A serotonin precursor — see the interaction note above |
| 5-HTP (5-hydroxytryptophan) | A serotonin precursor — see the interaction note above |
| Taurine | An amino acid with a role in nervous system signalling |
| GABA (gamma-aminobutyric acid) | The main inhibitory neurotransmitter |
| Vitamin C (ascorbic acid) | A cofactor in neurotransmitter synthesis |
| Baicalin | A flavonoid from Chinese skullcap |
| Apigenin | A flavonoid found in chamomile and parsley |
Other ingredients: vegetarian capsule (hypromellose, water). No fillers, binders or flow agents.
Individual amounts within the blend are not published. That is a fair thing to hold against any supplement, and we would rather state it plainly here than hope nobody checks the label. It is also the reason our evidence is a trial on the finished product rather than citations about single ingredients: when a blend hides doses, the only honest answer is to test the bottle itself. The method and results are on the trial page.
Bring the bottle or this page. Useful questions:
A pharmacist can answer most of this quickly and without an appointment, and they have your full medication list in front of them.
Two capsules, one hour before bed. That is the dose and the timing the trial used, and the only one we have data for. More is not better, and we have not tested it.
Four of the thirty people in the trial saw no change in their REM sleep over fourteen nights. If you run the 28-night test and your numbers do not move, that is a real result and it is worth acting on. The 30-day guarantee exists for exactly that outcome — we would rather refund you than have you keep buying something that is not working.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Nothing on this page is medical advice. Talk to a doctor or pharmacist about your own situation, particularly if you take prescription medication.